Spatiotemporal regulation of multistep enzyme reactions through compartmentalization is essential in studies that mimic natural systems such as cells and organelles. Until now, scientists have used ...

The enzyme accelerates this reaction by 10 17 times, simply by positioning negative and positive charges in the active centre. Since the substrate contains a negatively charged group that is split off ...

Researchers have uncovered the enzyme behind chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers. The enzyme, N4BP2, breaks apart DNA trapped in tiny cellular ...

Enzymes are amazing catalysts. These proteins are made of nothing more than a handful of Earth-abundant elements, and they promote a vast array of reactions, convert chemical energy to physical motion ...

Mitochondrial diseases are severe, often untreatable, and they leave human cells unable to grow normally without outside help. A new study published in Nature Metabolism now shows that a single gene ...

Proof of Concept is a video series profiling the science and scientists behind some of the environment’s most unexpected research. Pretty much all life on Earth – plants, animals, humans – in large ...

Enzymes help digest food, clean laundry, make perfumes, and build medicines. They also break down toxins in the environment. Because of their wide use, scientists have worked for years to create ...

Watching proteins move as they drive the chemical reactions that sustain life is one of the grand challenges of modern biology. In recent years, X-ray free-electron lasers, or XFELs, have begun to ...

The idea of deploying enzymes to break down plastic waste is gaining momentum through a string of breakthroughs demonstrating how they can do so with increasing efficiency, and even reduce the ...

Ancient enzymes show life’s nitrogen signal stayed unchanged for billions of years, helping scientists read early Earth.